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Good things come in (base) pairs Santiago Ramón y Cajal drew neurons. At booth 305, we’ll ask you to draw a dinosaur. Come visit the Plasmidsaurus team at SfN in Washington, DC, November 15–18! Stop by to: - Hear what’s new with Plasmidsaurus RNA-Seq and our other sequencing services - Add your art to our draw-a-dinosaur tradition - Grab our SfN exclusive dino merch 📌 Catch our poster (LBP052) on Tuesday, November 17, 1–5 p.m. Nicole Rapicavoli, PhD, Product Manager of RNA-Seq, is presenting “Charting the Transcriptional Life of the Mouse Hippocampus.” 🗣️ Presenting your own poster with data from Plasmidsaurus sequencing? We’d love to hear what you’re researching! Drop your poster number and session in the comments, and we’ll make sure to stop by. See you soon in DC! Finding the right gene to switch on is a needle-in-a-haystack problem, except the haystack is wrapped in nucleosomes. Transcription factors have to find a few specific DNA sequences among millions of near-matches. If one lingers at the wrong spot, genes that should stay off can accidentally switch on. So how do they stay on target? Wei et al. (2026) built a way to watch it happen. Using minichromosomes, which are small loops of DNA wrapped in real nucleosomes, the team tracked single molecules of the yeast transcription factor GCN4 as it searched for its target gene. The team verified their minichromosome constructs with Plasmidsaurus Whole Plasmid Sequencing, then used Plasmidsaurus Premium PCR Sequencing to map nucleosome positions and confirm the chromatin structure they were studying. Because the platform can be adapted to other chromatin-based processes, like DNA replication and repair, it opens a new window onto molecular events on native, protein-packaged DNA that were once hard to see. Plasmid errors are more common than you might think. According to Addgene’s Senior QC Manager, about 30% of plasmids they receive have sequence discrepancies that need depositor feedback. And those errors can quietly lead to failed cloning, irreproducible results, and wasted bench time. Be prepared to catch and prevent them by watching the Addgene × Plasmidsaurus webinar, now available on demand! The webinar breaks down: 🧬 What Sanger, short-read NGS, and long-read sequencing each reveal about your plasmid 📊 How to read your sequencing results, including consensus Q-scores 🚩 Warning signs that a construct has a problem Whether you're checking routine clones or validating a critical construct, walk away with a practical framework for choosing the right method and trusting your results. ▶️ Watch the recording in the “Resource Center” section of the Plasmidsaurus website. For the record, we sequence your nucleic acids. We do not eat them 😉 Happy Halloween! 🎃 Beware of what may be lurking about…👻🦖 Stuck on an RNA-Seq question? Ask the people who helped build Plasmidsaurus RNA-Seq. Justin Blethrow, PhD, and Nicole Rapicavoli, PhD, from our RNA-Seq product team are hosting a virtual user group meeting on November 12. Here’s what to expect: 🦖 Product updates on what’s new with Plasmidsaurus RNA-Seq 🖥️ Live demos 🧪 Workflow tips, from sample prep to data analysis 🙋 Answers to real questions from the community 📅 Thursday, November 12, 2026 🕚 11 a.m. Pacific / 2 p.m. Eastern 📍 Online Got a question you want covered? Submit it on the event page when you register. 🔗 Registration link in Bio Science runs on data, rigor, and…picking the right ice bucket? Swipe to see some lab superstitions our team won’t risk breaking. What’s yours? Confess in the comments 👀 Lab safety question of the day: how does a dinosaur wear safety glasses? 🦖🥽 Triceratops had it easy. For everyone else, we drew up a few workarounds. Have a better solution? Tell (or show) us in the comments.
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