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Channeling Paul’s optimism for this Monday. Results may vary.

Nodding along while mentally refreshing your inbox

There's no good time to discover your plasmid is wrong, but finding out months into a project is the worst. 👀

Did you know Addgene's QC team reports finding errors in about 30% of deposited plasmids? Not every error will compromise a construct, but an unexpected one can mean weeks of frustrating troubleshooting.

Fortunately, Plasmidsaurus Whole Plasmid Sequencing can help you catch issues before they derail your project.

But when should you actually sequence your whole plasmid? Our latest blog post breaks down four key moments when it makes all the difference.

🔗Link to blog in Bio

Whether it’s your 1st or 50th, every submission is worth celebrating 🎉

Ambrosia beetles are farmers. They carry fungi in special pockets on their bodies and grow them as food, a partnership that has evolved independently at least a dozen times. But when these beetles spread to new regions, some of their fungal crops become devastating tree killers. Until recently, researchers lacked the genetic tools to study many of them.

In a study published in Fungal Biology and Biotechnology, Joseph et al. (2026) show that genetic tools developed for one ambrosia beetle fungus can be used to genetically modify several of its diverse relatives.

To build these tools, the researchers used Plasmidsaurus ZeroPrep to verify that their plasmids contained the intended sequences.

This work opens the door to studying how these partnerships work, and how some turn harmful.

With its enormous claws, Therizinosaurus looked like a formidable predator. But this dinosaur was likely a herbivore, a reminder that appearances don’t always tell the whole story.

The same can be true for cell cultures.

Mycoplasma can alter cell signaling and gene expression without causing obvious changes in the culture. Everything may look fine while unwanted contamination affects the biology you’re trying to measure.

Your RNA-Seq data can help uncover what isn’t visible. Plasmidsaurus now includes mycoplasma screening with all RNA-Seq results. We analyze non-host reads and screen for nine mycoplasma and related species, looking for strong evidence of contamination.

No extra sample or additional sequencing, just more insight from data you’re already generating.

Is your HEK293 really HEK293?

Cell line misidentification is more common than you might think. The International Cell Line Authentication Committee estimates the worldwide average incidence of misidentified cell line use at 22%.

Now every Plasmidsaurus RNA-Seq order checks for you. We use the SNPs already captured in your RNA-Seq reads to confirm sample identity, so there's no separate assay and no extra sequencing step.

With this approach, Plasmidsaurus can:
- Compare human samples against 917 cataloged cell lines
- Flag potential mixtures when a second measured cell line accounts for 10% or more of reads
- Assign mouse samples to 45 strain background groups

🔗 Link in Bio to the full technical note

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