Breakthroughs happen when the barriers disappear. At Plasmidsaurus, we’re on a mission to democratize science and build a "biotech-for-all" future by eliminating the technical bottlenecks that slow down great ideas. Today, we are taking that mission to the next level.
We are officially announcing a four-year strategic partnership with an amazing company that shares and embodies this vision: Addgene.
Two Organizations, One Goal
Addgene is one of the world's biggest plasmid repositories, and is the global heart of open-source science. They have spent decades building the ultimate library for scientific sharing, making sure that when one researcher discovers something incredible, the rest of the world can build on it.
As Addgene’s repository expands, they need a sequencing partner that can keep pace with today’s ever increasing rate of submissions. That’s where we come in. Plasmidsaurus will now be handling the majority of Addgene’s plasmid sequencing, ensuring that the global research community has access to the most reliable, verified genetic tools ever created.
Proof in Practice: Addgene’s Sequencing Evolution
Addgene has always prioritized the highest standards of quality and reliability. This is why every plasmid hosted on Addgene is sequenced upon submission. Over the years, Addgene has always sought the best sequencing approach that could be scalably implemented for their growing collection. Our partnership with Addgene represents the next step in their quest for state-of-the-art sequencing to provide the most accurate plasmid maps and high-quality DNA constructs.
Addgene’s current workflow is to verify all plasmids using next generation sequencing, with rigorous analysis on every result. This partnership represents the next step in that evolution: shifting to long-read sequencing for the vast majority of plasmid verification, combining Plasmidsaurus' highly accurate sequencing with Addgene's established QC analysis and curation. The result is a collection that researchers can rely on- fully sequenced, rigorously reviewed, and verified to the highest standard.
Why This Matters for the Research Community
This partnership is about making sure the accuracy, transparency, and accessibility of plasmid data is the best it can possibly be for every scientist in the global research community. By combining Addgene’s expertly curated collection with our whole plasmid sequencing technology, we are ensuring that the tools you rely on are verified with the highest possible standards.
The Plasmidsaurus Advantage
We pioneered whole plasmid sequencing because we were tired of the problems that have plagued biologists for decades. For too long, bench scientists were stuck using outdated Sanger methods that revealed only fragments of DNA, often leading to invisible backbone errors, painful project failures, and weeks of troubleshooting. Our approach changes the game:
- Completeness and Accuracy: Using the newest long-read sequencing technology from Oxford Nanopore Technologies (ONT), we generate contiguous reads spanning entire plasmids. This ensures total structural accuracy and verifies plasmid identity, purity, and stability.
- Unmatched Precision: Our automated custom analysis pipeline delivers >99.9% basecall accuracy. Consensus accuracy often reaches Q60 (that’s 99.9999%!), or just one error per 1,000,000 bases, allowing you to zero in on mutations, insertions, and deletions instantly.
- Zero Primers Required: We save you time and money by eliminating the need for custom primers, making the transition from bench to data seamless.
- Ultrafast Results: Our global network of labs operates day and night to deliver automated results overnight. You get answers to your most critical questions (Is my sequence correct? Is my sample contaminated?) so you can focus on the next experiment, with no bioinformatics expertise required.
Fueling the Future of Discovery
Since launching in 2021, we have sequenced over 5 million plasmids for thousands of innovators, from Nobel Prize winners to first-year PhD students. By joining forces with Addgene, we are ensuring that the most critical tools in biology are backed by the most definitive data available.
We are proud to support scientists who are at the bench every day, putting in the hard work and know what it’s like to live for the data but struggle with the prep. Whether you’re meticulously scraping the last of a 'low-yield' pellet or praying the vacuum manifold doesn't lose suction mid-column, we've been there, we see you. We’re proud to back the scientists who get their hands dirty at the bench every day, turning "what if" into "it works" one tube at a time.
Together, we're sequencing today's plasmids and accelerating tomorrow's breakthroughs.
Ready to see what primer-free whole plasmid sequencing looks like for your own projects? Explore our Plasmidsaurus sequencing services or head over to Addgene to find your next community contributed plasmid.