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🦠 What if we could make bacterial biofilms easier to break?

A new study published in PLOS Pathogens by Piazza et al. (2026) uncovered a previously unknown pathway that helps Pseudomonas aeruginosa build stable biofilms and survive antibiotics.

The researchers identified a new biofilm regulatory protein, BatR, and found that it interacts with the stress response enzyme SrkA in a previously unknown signaling network.

Plasmidsaurus Whole Genome Sequencing of P. aeruginosa escape mutants provided clues about how bacteriophage Pf4 contributes to cell death and eDNA release in mature biofilms.

Swipe through to explore what these findings could mean for understanding biofilms and making chronic infections more vulnerable to treatment.

A published analysis of 9,395 public RNA-Seq samples across 884 projects found mycoplasma contamination in 11% of samples.

That’s not a small number, and it’s easy to miss. Mycoplasma can affect cell growth, metabolism, and gene expression without obvious changes in culture appearance.

Starting now, every Plasmidsaurus RNA-Seq result includes mycoplasma screening at no additional cost. Identify potential contamination before it becomes a confounding variable in your analysis.

🍺 Can yeast collected from a 250-year-old tree recreate colonial-style beer?

This question was explored by The Bochman Group, who study DNA helicases and genome integrity using the model organism Saccharomyces cerevisiae. Earlier this year, they put an unusual yeast to the test: S. cerevisiae DoF1, collected from a 250-year-old oak tree.

Along the way, they made a discovery about the yeast’s genome integrity and identity. Plasmidsaurus Whole Genome Sequencing revealed that their yeast isolate, S. cerevisiae DoF1, was a bona fide wild strain—not a lab strain or brewery contaminant.

Swipe through to see what unusual yeasts might teach us about evolution, ecology, and fermentation biology.

“We knew what we had to do. We just couldn’t do it fast enough.” — Nikolas Balanis, CTO of Syntax Bio

For cell engineering teams, rapid iteration depends on fast access to high-quality sequence data. That’s especially true for Syntax Bio, which uses CRISPR to reprogram stem cells with the goal of bringing stem-cell-derived therapies to patients who need them.

In our latest case study, Syntax Bio shares how Plasmidsaurus RNA-Seq and Whole Plasmid Sequencing fit into their workflow. Faster construct verification and transcriptome-wide readouts helped the team move efficiently from experimental design to actionable data, giving them the bandwidth to optimize designs at a scale that was previously impractical.

🔗 Link to case study in Bio

What if antibiotic resistance could spread between bacteria inside a patient’s lungs?

Published in Nature Microbiology, Karash et al. (2026) show that resistance-carrying plasmids can move between bacterial species inside patients’ lungs during chronic infections, rapidly spreading antibiotic resistance.

The researchers identified plasmids carrying aminoglycoside resistance genes, including the newly identified aac(3)-IIId. Likely originating from environmental bacteria, these plasmids transferred between species and conferred resistance to tobramycin.

To uncover how this was happening, the team used Plasmidsaurus Whole Genome Sequencing to resolve complete bacterial genomes and plasmids from more than 140 clinical isolates.

Swipe to learn more.

Missed our webinar on making RNA-seq more practical for everyday research?

The recording of “3′ RNA-Seq for Everyday Sequencing: A New Paradigm for Transcriptomics” is now available to watch!

RNA-seq has transformed how we study gene expression, but cost, turnaround time, and workflow complexity can still make routine experiments challenging.

In this webinar, we cover:
🧬 Fast, affordable RNA-seq with 3′ end counting
📊 Automated analysis and an interactive results viewer
🔬 Real-world applications, including insights from Alex M. Abel (Co-founder and CSO at VelociTx Inc.) as our guest scientist

▶️ Watch the recording in the “Resource Center” section of the Plasmidsaurus website.

What are the dinos up to in lab today? 🧪

People say Plasmidsaurus is cute, but that’s the least interesting thing about us…

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