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Whitepaper: RNA-Seq, Optimized for Everyday Discovery

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Charting the Transcriptional Life of the Mouse Hippocampus and Cortex

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Permission to skip the miniprep. Send us colonies with ZeroPrep and you’ll still get your plasmid sequencing results 😏

Say “ahh”: one of the most common cell culture contaminants naturally lives in your mouth.

Besides human-associated sources, your cells can pick up mycoplasma from other contaminated cultures, shared equipment, or contaminated reagents.

Once mycoplasma infects your cell culture, it:
🧫 Doesn’t cloud your media or shift its pH
💊 Resists most routine antibiotics
🔬 Quietly changes how your cells behave

Swipe to see how it spreads, how different tests catch it, and how your Plasmidsaurus RNA-Seq data can now flag it too.

Sources: Drexler & Uphoff, Cytotech. (2002); Olarerin-George & Hogenesch, Nucleic Acids Res. (2015); RIKEN BRC Cell Bank; Plasmidsaurus Mycoplasma Technical Note (2026)

Colonies on the plate and a decision at the bench: miniprep first, or sequence first?

Follow Xiaoxuan, a UCSF scientist in the labs of Yifan Cheng and Nobel laureate David Julius, as she puts Whole Plasmid Sequencing and ZeroPrep Colony Sequencing head-to-head in her own workflow.

With ZeroPrep, she can start her next experiments a day sooner. The faster you confirm your clones, the faster you can get back to the science that matters to you.

See what it’s like to get miniprep-quality results straight from a colony. Give ZeroPrep a try 😏

Good things come in (base) pairs

Santiago Ramón y Cajal drew neurons. At booth 305, we’ll ask you to draw a dinosaur.

Come visit the Plasmidsaurus team at SfN in Washington, DC, November 15–18!

Stop by to:
- Hear what’s new with Plasmidsaurus RNA-Seq and our other sequencing services
- Add your art to our draw-a-dinosaur tradition
- Grab our SfN exclusive dino merch

📌 Catch our poster (LBP052) on Tuesday, November 17, 1–5 p.m.

Nicole Rapicavoli, PhD, Product Manager of RNA-Seq, is presenting “Charting the Transcriptional Life of the Mouse Hippocampus.”

🗣️ Presenting your own poster with data from Plasmidsaurus sequencing? We’d love to hear what you’re researching! Drop your poster number and session in the comments, and we’ll make sure to stop by.

See you soon in DC!

Finding the right gene to switch on is a needle-in-a-haystack problem, except the haystack is wrapped in nucleosomes.

Transcription factors have to find a few specific DNA sequences among millions of near-matches. If one lingers at the wrong spot, genes that should stay off can accidentally switch on. So how do they stay on target?

Wei et al. (2026) built a way to watch it happen. Using minichromosomes, which are small loops of DNA wrapped in real nucleosomes, the team tracked single molecules of the yeast transcription factor GCN4 as it searched for its target gene.

The team verified their minichromosome constructs with Plasmidsaurus Whole Plasmid Sequencing, then used Plasmidsaurus Premium PCR Sequencing to map nucleosome positions and confirm the chromatin structure they were studying.

Because the platform can be adapted to other chromatin-based processes, like DNA replication and repair, it opens a new window onto molecular events on native, protein-packaged DNA that were once hard to see.

Plasmid errors are more common than you might think.

According to Addgene’s Senior QC Manager, about 30% of plasmids they receive have sequence discrepancies that need depositor feedback. And those errors can quietly lead to failed cloning, irreproducible results, and wasted bench time.

Be prepared to catch and prevent them by watching the Addgene × Plasmidsaurus webinar, now available on demand!

The webinar breaks down:
🧬 What Sanger, short-read NGS, and long-read sequencing each reveal about your plasmid
📊 How to read your sequencing results, including consensus Q-scores
🚩 Warning signs that a construct has a problem

Whether you're checking routine clones or validating a critical construct, walk away with a practical framework for choosing the right method and trusting your results.

▶️ Watch the recording in the “Resource Center” section of the Plasmidsaurus website.

For the record, we sequence your nucleic acids. We do not eat them 😉

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